Joann Xie, L.Ac
publications
1. Zhao L, Guo Z, Chen Y, Hu T, Wu D, Zhu YF, Rowbottom MW, Gross TD, Tucci FC, Struthers RS, Xie Q, Chen
C. 5-Aryluracils as potent GnRH antagonists-Characterization of atropisomers. Bioorg Med Chem Lett. 2008 Jun 118
(11):3344-9.
2. Chen C, Chen Y, Pontillo J, Guo Z, Huang CQ, Wu D, Madan A, Chen T, Wen J, Xie Q, Tucci FC, Rowbottom MW, Zhu YF, Wade W, Bozigian H, Struthers RS. Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activity. Bioorg Med Chem Lett. 2008 Jun 118(11):3301-5.
3. Trudy A. Kohout, Qiu Xie, Shelby Reijmers, Kenneth J. Finn, Zhiqiang Guo, Yun-Fei Zhu, and R. Scott Struthers. Ligand Trapping by the Extracellular Domains of the Gonadotropin-releasing Hormone Receptor Results in the Insurmountability of a Nonpeptide Antagonist. Mol Pharmacol. Mol Pharmacol. 2007 Aug 72(2):238-47.
4. Struthers RS, Xie Q, Sullivan SK, Reinhart GJ, Kohout TA, Zhu YF, Chen C, Liu XJ, Ling N, Yang W, Maki RA, Bonneville AL, Chen TK and Bozigian H. Pharmacologic characterization of a novel nonpeptide antagonist of the human GnRH receptor, NBI-42902. (Endocrinology, 2007 Feb 148(2):857-67)
5. Guo Z, Chen Y, Huang CQ, Gross TD, Pontillo J, Rowbottom MW, Saunders J, Struthers RS, Tucci FC, Xie Q, Wade W, Zhu YF, Wu D, Chen C. Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers. Bioorg Med Chem Lett. 2005 May 1615(10):2519-22.
6. Tucci FC, Zhu YF, Struthers RS, Gross TD, Acevedo O, Gao Y, Saunders J, Xie Q, Reinhart GJ, Liu XJ, Ling N, Bonneville AL, Chen TK, Bozigian H, Chen C. 3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3- methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor. Design, synthesis, and in vitro and in vivo characterization. J Med Chem. 2005 Feb 2448(4):1169-78.
7. Reinhart GJ, Xie Q, Liu XJ, Zhu YF, Fan J, Chen C, Struthers RS. Species selectivity of nonpeptide antagonists of the gonadotropin-releasing hormone receptor is determined by residues in extracellular loops II and III and the amino terminus. J Biol Chem. 2004 Aug 13279(33):34115-22.
8. Rowbottom MW, Tucci FC, Connors PJ Jr, Gross TD, Zhu YF, Guo Z, Moorjani M, Acevedo O, Carter L, Sullivan SK, Xie Q, Fisher A, Struthers RS, Saunders J, Chen C. Synthesis and structure-activity relationships of uracil derived human GnRH receptor antagonists: (R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils containing a substituted thiophene or thiazole at C-5. Bioorg Med Chem Lett. 2004 Oct 414(19):4967-73.
9. Tucci FC, Zhu YF, Guo Z, Gross TD, Connors PJ Jr, Gao Y, Rowbottom MW, Struthers RS, Reinhart GJ, Xie Q, Chen TK, Bozigian H, Killam Bonneville AL, Fisher A, Jin L, Saunders J, Chen C. 3-(2-aminoalkyl)-1-(2,6-difluorobenzyl) -5- (2-fluoro-3-methoxyphenyl)-6-methyl-uracils as orally bioavailable antagonists of the human gonadotropin releasing hormone receptor. J Med Chem. 2004 Jul 147(14):3483-6.
10. Rowbottom MW, Tucci FC, Zhu YF, Guo Z, Gross TD, Reinhart GJ, Xie Q, Struthers RS, Saunders J, Chen C. Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists. Bioorg Med Chem Lett. 2004 May 314(9):2269-74.
11. Guo Z, Zhu YF, Gross TD, Tucci FC, Gao Y, Moorjani M, Connors PJ Jr, Rowbottom MW, Chen Y, Struthers RS, Xie Q, Saunders J, Reinhart G, Chen TK, Bonneville AL, Chen C. Synthesis and structure-activity relationships of 1- arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonists. J Med Chem. 2004 Feb 2647(5):1259-71.
12. Guo Z, Chen Y, Wu D, Zhu YF, Struthers RS, Saunders J, Xie Q, Chen C. Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidine-2,4-dione derivatives as potent GnRH receptor antagonists. Bioorg Med Chem Lett. 2003 Oct 2013(20):3617-22.
13. Guo Z, Zhu YF, Tucci FC, Gao Y, Struthers RS, Saunders J, Gross TD, Xie Q, Reinhart G, Chen C. Synthesis and structure-activity relationships of 1-arylmethyl-3-(2-aminopropyl)-5-aryl-6-methyluracils as potent GnRH receptor antagonists. Bioorg Med Chem Lett. 2003 Oct 613(19):3311-5.
14. YF Zhu, Z Guo, T Gross, Y Gao, P Connors, R Struthers, Q Xie, G Reinhart, F Tucci, D Wu, J Saunders, C Chen. Design and structure-activity relationship of 2-Alkyl-3-amniomethyl-6-(3-methoxyphenyl)-7-methyl-8-(2- fluorobenzyl)imidazolo-[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists. J Med Chem. 2003 Apr 2446(9): 1769-72.
15. YF Zhu, K Wilcoxen, T Gross, P Connors, N Strack, R Gross, CQ Huang, JR McCarthy, Q Xie, N Ling, C Chen. 6,7-Dihydroxyisoquinoline-3-carboxylic acids are potent inhibitors on the binding proteins: optimization of the 1-position benzoyl side chain. Bioorg. Med Lett. (2003) 13:1927-1930.
16. YF Zhu, XC Wang, P Connors, K Wilcoxen, Y Gao, R Gross, N Strack, T Gross, JR McCarthy, Q Xie, N Ling and C Chen. Quinoline-Carboxylic Acids are potent inhibitors that inhibit the binding of Insulin-like growth factor (IGF) to IGF-Binding proteins. Bioorg. Med. Chem. Lett., (2003) 13:1931-1934.
17. Y-F Zhu, K. Wilcoxen, J. Saunders, Z. Guo, Y. Gao, P.J. Connors Jr., T.D. Gross, F.C. Tucci, R.S. Struthers, G. J. Reinhart, Q. Xie and C. Chen (2001). A Novel Synthesis of 2-Arylpyrrolo[1,2-α]pyrimid-7-ones and Their Structure- Activity Relationships as Potent GnRH Receptor Antagonists. Bioorg. Med. Chem. Lett., 2002 Feb 11:12(3):403-6.
18. Chen C, Zhu YF, Liu XJ, Lu ZX, Xie Q, Ling N. (2001). Discovery of a Series of Nonpeptide Small Molecules That Inhibit the Binding of Insulin-like Growth Factor (IGF) to IGF-Binding Proteins. J Med Chem. Nov 844(23):4001-10.
19. Liu XJ, Xie Q, Zhu YF, Chen C, Ling N. (2001). Identification of a nonpeptide ligand that releases bioactive insulin- like growth factor-I from its binding protein complex. J Biol Chem. Aug 31276(35):32419-22.
20. D Maciejewski-Lenoir, SC Heinrichs, XJ Liu, N Ling, A Tucker, Q Xie, DA Lappi and DE Grigoriadis. Selective impairment of corticotropin-releasing factor 1 (CRF-1) receptor-mediated function using CRF coupled to saporin. Endocrinology 2000 Feb:141(2):498-504.
21. Li S.A., Xue Y., Xie Q., Li C.I. and Li J.J. Serum and tissue levels of estradiol during estrogen-induced renal tumorigenesis in the Syrian hamster. J Steroid Biochem Mol Biol 48:283-286, 1994.
2. Chen C, Chen Y, Pontillo J, Guo Z, Huang CQ, Wu D, Madan A, Chen T, Wen J, Xie Q, Tucci FC, Rowbottom MW, Zhu YF, Wade W, Bozigian H, Struthers RS. Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activity. Bioorg Med Chem Lett. 2008 Jun 118(11):3301-5.
3. Trudy A. Kohout, Qiu Xie, Shelby Reijmers, Kenneth J. Finn, Zhiqiang Guo, Yun-Fei Zhu, and R. Scott Struthers. Ligand Trapping by the Extracellular Domains of the Gonadotropin-releasing Hormone Receptor Results in the Insurmountability of a Nonpeptide Antagonist. Mol Pharmacol. Mol Pharmacol. 2007 Aug 72(2):238-47.
4. Struthers RS, Xie Q, Sullivan SK, Reinhart GJ, Kohout TA, Zhu YF, Chen C, Liu XJ, Ling N, Yang W, Maki RA, Bonneville AL, Chen TK and Bozigian H. Pharmacologic characterization of a novel nonpeptide antagonist of the human GnRH receptor, NBI-42902. (Endocrinology, 2007 Feb 148(2):857-67)
5. Guo Z, Chen Y, Huang CQ, Gross TD, Pontillo J, Rowbottom MW, Saunders J, Struthers RS, Tucci FC, Xie Q, Wade W, Zhu YF, Wu D, Chen C. Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers. Bioorg Med Chem Lett. 2005 May 1615(10):2519-22.
6. Tucci FC, Zhu YF, Struthers RS, Gross TD, Acevedo O, Gao Y, Saunders J, Xie Q, Reinhart GJ, Liu XJ, Ling N, Bonneville AL, Chen TK, Bozigian H, Chen C. 3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3- methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor. Design, synthesis, and in vitro and in vivo characterization. J Med Chem. 2005 Feb 2448(4):1169-78.
7. Reinhart GJ, Xie Q, Liu XJ, Zhu YF, Fan J, Chen C, Struthers RS. Species selectivity of nonpeptide antagonists of the gonadotropin-releasing hormone receptor is determined by residues in extracellular loops II and III and the amino terminus. J Biol Chem. 2004 Aug 13279(33):34115-22.
8. Rowbottom MW, Tucci FC, Connors PJ Jr, Gross TD, Zhu YF, Guo Z, Moorjani M, Acevedo O, Carter L, Sullivan SK, Xie Q, Fisher A, Struthers RS, Saunders J, Chen C. Synthesis and structure-activity relationships of uracil derived human GnRH receptor antagonists: (R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils containing a substituted thiophene or thiazole at C-5. Bioorg Med Chem Lett. 2004 Oct 414(19):4967-73.
9. Tucci FC, Zhu YF, Guo Z, Gross TD, Connors PJ Jr, Gao Y, Rowbottom MW, Struthers RS, Reinhart GJ, Xie Q, Chen TK, Bozigian H, Killam Bonneville AL, Fisher A, Jin L, Saunders J, Chen C. 3-(2-aminoalkyl)-1-(2,6-difluorobenzyl) -5- (2-fluoro-3-methoxyphenyl)-6-methyl-uracils as orally bioavailable antagonists of the human gonadotropin releasing hormone receptor. J Med Chem. 2004 Jul 147(14):3483-6.
10. Rowbottom MW, Tucci FC, Zhu YF, Guo Z, Gross TD, Reinhart GJ, Xie Q, Struthers RS, Saunders J, Chen C. Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists. Bioorg Med Chem Lett. 2004 May 314(9):2269-74.
11. Guo Z, Zhu YF, Gross TD, Tucci FC, Gao Y, Moorjani M, Connors PJ Jr, Rowbottom MW, Chen Y, Struthers RS, Xie Q, Saunders J, Reinhart G, Chen TK, Bonneville AL, Chen C. Synthesis and structure-activity relationships of 1- arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonists. J Med Chem. 2004 Feb 2647(5):1259-71.
12. Guo Z, Chen Y, Wu D, Zhu YF, Struthers RS, Saunders J, Xie Q, Chen C. Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidine-2,4-dione derivatives as potent GnRH receptor antagonists. Bioorg Med Chem Lett. 2003 Oct 2013(20):3617-22.
13. Guo Z, Zhu YF, Tucci FC, Gao Y, Struthers RS, Saunders J, Gross TD, Xie Q, Reinhart G, Chen C. Synthesis and structure-activity relationships of 1-arylmethyl-3-(2-aminopropyl)-5-aryl-6-methyluracils as potent GnRH receptor antagonists. Bioorg Med Chem Lett. 2003 Oct 613(19):3311-5.
14. YF Zhu, Z Guo, T Gross, Y Gao, P Connors, R Struthers, Q Xie, G Reinhart, F Tucci, D Wu, J Saunders, C Chen. Design and structure-activity relationship of 2-Alkyl-3-amniomethyl-6-(3-methoxyphenyl)-7-methyl-8-(2- fluorobenzyl)imidazolo-[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists. J Med Chem. 2003 Apr 2446(9): 1769-72.
15. YF Zhu, K Wilcoxen, T Gross, P Connors, N Strack, R Gross, CQ Huang, JR McCarthy, Q Xie, N Ling, C Chen. 6,7-Dihydroxyisoquinoline-3-carboxylic acids are potent inhibitors on the binding proteins: optimization of the 1-position benzoyl side chain. Bioorg. Med Lett. (2003) 13:1927-1930.
16. YF Zhu, XC Wang, P Connors, K Wilcoxen, Y Gao, R Gross, N Strack, T Gross, JR McCarthy, Q Xie, N Ling and C Chen. Quinoline-Carboxylic Acids are potent inhibitors that inhibit the binding of Insulin-like growth factor (IGF) to IGF-Binding proteins. Bioorg. Med. Chem. Lett., (2003) 13:1931-1934.
17. Y-F Zhu, K. Wilcoxen, J. Saunders, Z. Guo, Y. Gao, P.J. Connors Jr., T.D. Gross, F.C. Tucci, R.S. Struthers, G. J. Reinhart, Q. Xie and C. Chen (2001). A Novel Synthesis of 2-Arylpyrrolo[1,2-α]pyrimid-7-ones and Their Structure- Activity Relationships as Potent GnRH Receptor Antagonists. Bioorg. Med. Chem. Lett., 2002 Feb 11:12(3):403-6.
18. Chen C, Zhu YF, Liu XJ, Lu ZX, Xie Q, Ling N. (2001). Discovery of a Series of Nonpeptide Small Molecules That Inhibit the Binding of Insulin-like Growth Factor (IGF) to IGF-Binding Proteins. J Med Chem. Nov 844(23):4001-10.
19. Liu XJ, Xie Q, Zhu YF, Chen C, Ling N. (2001). Identification of a nonpeptide ligand that releases bioactive insulin- like growth factor-I from its binding protein complex. J Biol Chem. Aug 31276(35):32419-22.
20. D Maciejewski-Lenoir, SC Heinrichs, XJ Liu, N Ling, A Tucker, Q Xie, DA Lappi and DE Grigoriadis. Selective impairment of corticotropin-releasing factor 1 (CRF-1) receptor-mediated function using CRF coupled to saporin. Endocrinology 2000 Feb:141(2):498-504.
21. Li S.A., Xue Y., Xie Q., Li C.I. and Li J.J. Serum and tissue levels of estradiol during estrogen-induced renal tumorigenesis in the Syrian hamster. J Steroid Biochem Mol Biol 48:283-286, 1994.
